Just follow what's been said here especially with soaking the threads with some Liquid Wrench or equivalent or at least some WD-40 a couple days before the work begins and again the day before. It shouldn't take you even close to two hours for a fender if your truck is fairly clean and not rusted too bad. I had mine off and a different fender back on in about 30 minutes but the bolts had been off just months earlier and I ran a tap through all the nuts and clips, a die over all of the bolts, and installed EVERY one of my front clip's bolts with some anti-seize (very nice!!!). Kaptn's got it down pretty well. The only thing I'd add would be to loosen the radiator core support mount on the side you're working on so you can get just a little fudging room when replacing the inner fender. You shouldn't have to remove the grille, bumper, valance, etc. unless you break some of the welded nuts in the core support or some of the threaded clips. I've now pulled about 3-4 pairs at the wrecking yard.
Not a bad idea with using the hoist but I'd also recommend chocking the hoist's wheels with little rocks as you don't want to move it around and damage the other hood hinge left in place!
It's really not too bad of a job and it'll help you get to know your truck a little better!
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The whole front clip is LOADED with bolts whereas other parts like the bed just have a handful holding everything in place. Good luck and have fun!
Patrick
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'56 F100; Must.II IFS, 351W bored & stroked to 395c.i. 470hp/483ft-lbs., AOD, 4-link coilover 9" w/ 3.89's
'69 F100; 390, C6, Dana 60 w/ 4.10's
'70 F100; 'new' and latest project soon to have a built 390/C6 and 3.50 gears
To see more of my F100's:
http://www.cardomain.com/id/lowfat56