I remember some discussion on the F350 2wd has different body mount location that match the 4x4. Cant remember if the 2wd mounts will still work or 4x4 .
Yep the 2wd will work. Only difference is that the F100 f250 2wd mounts are on the inside of the frame rails on the 2wd F350 and the 4wd ones are outside the frame because of the transfercase. I have 2wd prothanes under mine.